Publications related to ESCALON

On this page you can find all publications related to ESCALON.

Cholangiocarcinoma – novel biological insights and therapeutic strategies

Ilyas, Sumera I., Silvia Affo, Lipika Goyal, Angela Lamarca, Gonzalo Sapisochin, Ju Dong Yang, and Gregory J. Gores.
Nature Reviews Clinical Oncology (2023): 1-17.
doi: 10.1038/s41571-023-00770-1

The promise of precision medicine: how biomarkers are shaping the future of cholangiocarcinoma treatment

Macias, Rocio IR, Lorenza Rimassa, and Angela Lamarca.
Hepatobiliary Surgery and Nutrition 12, no. 3 (2023): 457.
doi: 10.21037/hbsn-23-215

Chemotherapy with or without Selective Internal Radiation Therapy for intrahepatic cholangiocarcinoma: data from clinical trials

Edeline, Julien, John Bridgewater, Boris Campillo-Gimenez, Estelle Neveu, Jean-Marc Phelip, Cindy Neuzillet, Karim Boudjema et al.
Hepatology (2023): 10-1097.
doi: 10.1097/HEP.0000000000000544

Epidemiology and risk factors for histopathologic characteristics of non-alcoholic fatty liver disease in South America

Akambase, Joseph A., Jhon E. Prieto, Angelo Z. Mattos, Angelo A. Mattos, Enrique Carrera, Javier Díaz‐Ferrer, Patricia Gallardo et al.
Alimentary Pharmacology & Therapeutics (2023).
doi: 10.1111/apt.17615

Criteria for preclinical models of cholangiocarcinoma: scientific and medical relevance

Calvisi, Diego F., Luke Boulter, Javier Vaquero, Anna Saborowski, Luca Fabris, Pedro M. Rodrigues, Cédric Coulouarn et al.  
Nature Reviews Gastroenterology & Hepatology (2023): 1-19.
doi: 10.1038/s41575-022-00739-y

Hepatocellular carcinoma in non-alcoholic steatohepatitis without cirrhosis.

Tovo, Cristiane Valle, Angelo Zambam de Mattos, Gabriela Perdomo Coral, Giovana DP Sartori, Livia Villela Nogueira, Gustavo Tovo Both, Cristiane A. Villela-Nogueira, and Angelo A. de Mattos.
World Journal of Gastroenterology 29, no. 2 (2023): 343.
doi: 10.3748/wjg.v29.i2.343

MicroRNA-27a-3p targets FoxO signalling to induce tumour-like phenotypes in bile duct cells.

Duwe, Lea, Patricia Munoz-Garrido, Monika Lewinska, Juan Lafuente-Barquero, Letizia Satriano, Dan Høgdall, Andrzej Taranta et al.
Journal of hepatology 78, no. 2 (2023): 364-375.
doi: 10.1016/j.jhep.2022.10.012.

A3907, a systemic ASBT inhibitor, improves cholestasis in mice by multi-organ activity and shows translational relevance to humans.

Caballero, Francisco J., Pedro Miguel Rodrigues, Aloña Agirre Lizaso, Paula Olaizola, Laura Izquierdo-Sánchez, María Jesús Perugorria, Luis Bujanda et al. 
Journal of Hepatology 78 (2023): S62.
doi: 10.1097/HEP.0000000000000376

PFKFB4 Is a Metabolic Driver of HCC Progression and Chemoresistance Through ROS Mitigation

Olaizola, Paula, and Jesus M. Banales.
Cellular and Molecular Gastroenterology and Hepatology 15, no. 6 (2023): 1527
doi: 10.1016/j.jcmgh.2023.02.015

Liquid biopsy-based protein biomarkers for risk prediction, early diagnosis, and prognostication of cholangiocarcinoma

Lapitz, Ainhoa, Mikel Azkargorta, Piotr Milkiewicz, Paula Olaizola, Ekaterina Zhuravleva, Marit M. Grimsrud, Christoph Schramm et al.
Journal of hepatology. 2023 Mar 1.
doi: 10.1016/j.jhep.2023.02.027

Hepatocellular carcinoma

Arndt Vogel, Tim Meyer, Gonzalo Sapisochin, Riad Salem, Anna Saborowski
Lancet. 2022 Oct 15;400(10360):1345-1362. Epub 2022 Sep 6
doi: 10.1016/S0140-6736(22)01200-4.


What is the gender representation in authorship in later phase systemic clinical trials in biliary tract cancer (BTC)? - a retrospective review of the published literature

Mairéad G McNamara, John Bridgewater, Lipika Goyal, Timothy Jacobs, Anna D Wagner, David Goldstein, Rachna Shroff, Markus Moehler, Maeve Lowery, Tanios Bekaii-Saab, Robin K Kelley, Junji Furuse, Lorenza Rimassa, Chigusa Morizane, Angela Lamarca, Richard Hubner, Jennifer Knox, Juan Valle
BMJ Open 2022 Oct 26;12(10):e064954.
doi: 10.1136/bmjopen-2022-064954.

Molecular profiling and precision medicine in rare gastrointestinal cancers within EURACAN in the SPECTA Arcagen study (EORTC-1843): too few patients treated in Europe.

A Lamarca, M Morfouace, S Tejpar, J Oliveira, A Capela, N Penel, C Gennigens, B Brasiuniene, J Peron, A Stevovic, J-Y Blay, H-J Klümpen.
Ann Oncol. 2022 Nov;33(11):1200-1202. Epub 2022 Aug 1.
doi: 10.1016/j.annonc.2022.07.006.

Use of the Rockwood Clinical Frailty Scale in patients with advanced hepatopancreaticobiliary malignancies. Expert Review of Anticancer Therapy

Dinakshi Shah, Zainul Abedin Kapacee, Angela Lamarca, Richard A Hubner, Juan W Valle, Mairéad G McNamara
Expert Rev Anticancer Ther. 2022 Sep;22(9):1009-1015. Epub 2022 Jul 6.
doi: 10.1080/14737140.2022.2096594. 

Non-alcoholic fatty liver disease-related hepatocellular carcinoma: Is there a role for immunotherapy?

Ângelo Z Mattos, Jose D Debes, Arndt Vogel, Marco Arrese, Xavier Revelo, Tales Henrique S Pase, Muriel Manica, Angelo A Mattos 
World J Gastroenterol. 2022 Jul 28;28(28):3595-3607.
doi: 10.3748/wjg.v28.i28.3595.

Changing epidemiology of hepatocellular carcinoma in South America: a report from the South American Liver Research Network

Marina Faraha, Chimaobi Anugwomb, Javier Diaz Ferrerc, Estefania Liza Bacac, Angelo Z. Mattosd, João Pedro P. Possebond, Marco Arresee, Jhon Prietof, Domingo Balderramog, Enrique Carrerah, Jose D. Debes
Ann Hepatol. 2022 Nov 15;28(2):100876.
doi: 10.1016/j.aohep.2022.100876. 

Hepatocellular carcinoma in Hepatitis B and Human Immunodeficiency Virus coinfection in Africa: a focus on surveillance

Qian Wan, Chimaobi Anugwom, Hailemichael Desalegn , Jose D Debes
Hepatoma Res. 2022;8:39. Epub 2022 Oct 14
doi: 10.20517/2394-5079.2022.32. .

Circulating cytokines reflect the etiology-specific immune environment in cirrhosis and HCC

Beudeker BJB, Groothuismink ZMA, van der Eijk AA, Debes JD, Boonstra A. 
Cancers (Basel). 2022 Oct 7;14(19):4900.
doi: 10.3390/cancers14194900.

Biliary tract cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up

Vogel A, Bridgewater J, Edeline J, Kelley RK, Klümpen HJ, Malka D, Primrose JN, Rimassa L, Stenzinger A, Valle JW, Ducreux M
Ann Oncol. 2022 Nov 10;S0923-7534(22)04699-3.
doi: 10.1016/j.annonc.2022.10.506.

Gallbladder cancer

Juan C. Roa, Patricia García, Vinay K. Kapoor, Shishir K. Maithel, Milind Javle, Jill Koshiol 
Nat Rev Dis Primers. 2022 Oct 27;8(1):69.
doi: 10.1038/s41572-022-00398-y.

Environmental and lifestyle risk factors in the carcinogenesis of gallbladder cancer

Pérez-Moreno P, Riquelme I, García P, Brebi P, Roa JC. 
J Pers Med. 2022 Feb 8;12(2):234.
doi: 10.3390/jpm12020234.

Dysplasia and carcinoma of the gallbladder: pathological evaluation, sampling, differential diagnosis and clinical implications

Juan C Roa, Olca Basturk, Volkan Adsay.
Histopathology. 2021 Jul;79(1):2-19.
doi: 10.1111/his.14360.

The Emerging Role of PIWI-Interacting RNAs (piRNAs) in Gastrointestinal Cancers: An Updated Perspective

Riquelme I, Pérez-Moreno P, Letelier P, Brebi P, Roa JC.
Cancers. 2021 Dec 31;14(1):202.
doi: 10.3390/cancers14010202.

Intrahepatic cholangiocarcinoma hidden within cancer of unknown primary

Alicia-Marie Conway, Georgina C. Morris, Sarah Smith, Monique Vekeria, Prakash Manoharan, Claire Mitchell, Alison Backen, Pedro Oliveira, Richard A. Hubner, Angela Lamarca, Mairéad G. McNamara, Juan W. Valle and Natalie Cook.
Br J Cancer. 2022 Aug;127(3):531-540.
doi: 10.1038/s41416-022-01824-4

Use of the Rockwood Clinical Frailty Scale in patients with advanced hepatopancreaticobiliary malignancies

Dinakshi Shah, Zainul Abedin Kapacee, Angela Lamarca, Richard A Hubner, Juan W Valle & Mairéad G McNamara.
Expert Rev Anticancer Ther. 2022 Jul 6;1-7.
doi: 10.1080/14737140.2022.2096594

Molecular profiling and precision medicine in rare gastrointestinal cancers within EURACAN in the SPECTA Arcagen study (EORTC-1843): too few patients treated in Europe.

Angela Lamarca, Marie Morfouace, Sabine Tejpar, Julio Oliveira, Andreia Capela, Nicolas Penel, Christine Gennigens, Birute Brasiuniene, Julien Peron, Aleksandra Stevovic, Jean-Yves Blay, Heinz-Josef Klümpen.
Annals of Oncology. July 31, 2022
Doi: 10.1016/j.annonc.2022.07.006

PIGR-enriched circulating vesicles contributes to hepatocellular carcinoma aggressiveness

Zingoni A, Banales JM.
J Hepatol. 2022 Apr;76(4):768-770.
doi: 10.1016/j.jhep.2022.02.001.

Cholangiocarcinoma landscape in Europe: Diagnostic, prognostic and therapeutic insights from the ENSCCA Registry.

Izquierdo-Sanchez L, Lamarca A, La Casta A, Buettner S, Utpatel K, Klümpen HJ, Adeva J, Vogel A, Lleo A, Fabris L, Ponz-Sarvise M, Brustia R, Cardinale V, Braconi C, Vidili G, Jamieson NB, Macias RI, Jonas JP, Marzioni M, Hołówko W, Folseraas T, Kupčinskas J, Sparchez Z, Krawczyk M, Krupa Ł, Scripcariu V, Grazi GL, Landa-Magdalena A, Ijzermans JN, Evert K, Erdmann JI, López-López F, Saborowski A, Scheiter A, Santos-Laso A, Carpino G, Andersen JB, Marin JJ, Alvaro D, Bujanda L, Forner A, Valle JW, Koerkamp BG, Banales JM.
J Hepatol. 2022 May;76(5):1109-1121.
doi: 10.1016/j.jhep.2021.12.010.

Clinical relevance of biomarkers in cholangiocarcinoma: critical revision and future directions

Macias RIR, Cardinale V, Kendall TJ, Avila MA, Guido M, Coulouarn C, Braconi C, Frampton AE, Bridgewater J, Overi D, Pereira SP, Rengo M, Kather JN, Lamarca A, Pedica F, Forner A, Valle JW, Gaudio E, Alvaro D, Banales JM, Carpino G.
Gut. 2022 Aug;71(8):1669-1683.
doi: 10.1136/gutjnl-2022-327099.

New molecular mechanisms in cholangiocarcinoma: signals triggering interleukin-6 production in tumor cells and KRAS co-opted epigenetic mediators driving metabolic reprogramming

Colyn L, Alvarez-Sola G, Latasa MU, Uriarte I, Herranz JM, Arechederra M, Vlachogiannis G, Rae C, Pineda-Lucena A, Casadei-Gardini A, Pedica F, Aldrighetti L, López-López A, López-Gonzálvez A, Barbas C, Ciordia S, Van Liempd SM, Falcón-Pérez JM, Urman J, Sangro B, Vicent S, Iraburu MJ, Prosper F, Nelson LJ, Banales JM, Martinez-Chantar ML, Marin JJG, Braconi C, Trautwein C, Corrales FJ, Cubero FJ, Berasain C, Fernandez-Barrena MG, Avila MA.
J Exp Clin Cancer Res. 2022 May 26;41(1):183.
doi: 10.1186/s13046-022-02386-2.

Understanding immune perspectives and options for the use of checkpoint immunotherapy in HCC post liver transplant

Chimaobi M Anugwom, Thomas M Leventhal, Jose D Debes.
Hepatoma Res. 2022;8:7.
doi: 10.20517/2394-5079.2021.123.

Potential influence of the microbiome environment in patients with biliary tract cancer and implications for therapy

Roseanna C Wheatley, Elaine Kilgour, Timothy Jacobs, Angela Lamarca, Richard A Hubner , Juan W Valle, Mairéad G McNamara.
Br J Cancer. 2022 Mar;126(5):693-705.
doi: 10.1038/s41416-021-01583-8.

Impact of Positive Lymph Nodes and Resection Margin Status on the Overall Survival of Patients with Resected Perihilar Cholangiocarcinoma: The ENSCCA Registry

Nooijen LE, Banales JM, de Boer MT, Braconi C, Folseraas T, Forner A, Holowko, W, Hoogwater FJH, Klümpen HJ, Groot, Koerkamp B, Lamarca A, La Casta A, López-López F, Izquierdo-Sánchez L, Scheiter A, Utpatel K, Swijnenburg RJ, Kazemier G, Erdmann JI;  ENSCCA Group.
Cancers (Basel). 2022 May 12;14(10):2389.
doi: 10.3390/cancers14102389.

Work-up and outcome of hepatic resection for perihilar cholangiocarcinoma (PH-CCA) without staging laparoscopy

Santhalingam Jegatheeswaran, Panagiotis Stathakis, Harry V M Spiers, Fawwaz Mohammed, Panagiotis Petras, Thomas Satyadas, Michael Parker, Angela Lamarca, Saurabh Jamdar, Aali J Sheen, Ajith Kumar Siriwardena.
Cancers (Basel). 2022 Apr 6;14(7):1841.
doi: 10.3390/cancers14071841.

Targeted therapies for Perihilar Cholangiocarcinoma

Gray, Simon, Angela Lamarca, Julien Edeline, Heinz-Josef Klümpen, Richard A. Hubner, Mairéad G. McNamara, and Juan W. Valle.
Cancers (Basel). 2022 Mar 31;14(7):1789.
doi: https://doi.org/10.3390/cancers14071789

Role of lncRNAs in the Development of an Aggressive Phenotype in Gallbladder Cancer

Pérez-Moreno P, Riquelme I, Brebi P, Roa JC.
Role of lncRNAs in the Development of an Aggressive Phenotype in Gallbladder Cancer. J Clin Med. 2021 Sep 17;10(18):4206.
doi: 10.3390/jcm10184206. PMID: 34575316; PMCID: PMC8468232.

A look back at cholangiocarcinoma in Finland

Izquierdo-Sanchez L, Banales JM, Rodrigues PM.
A look back at cholangiocarcinoma in Finland. United European Gastroenterol J. 2021 Dec;9(10):1103-1104.
doi: 10.1002/ueg2.12157. Epub 2021 Sep 28. PMID: 34581503; PMCID: PMC8672076.

Molecular diagnostics and therapies for gastrointestinal tumors: a real-world experience

Welland S, deCastro T, Bathon M, Wirth TC, Reineke-Plaaß T, Saborowski M, Lehmann U, Saborowski A, Vogel A.
Molecular diagnostics and therapies for gastrointestinal tumors: a real-world experience. J Cancer Res Clin Oncol. 2021 Aug 26.
doi: 10.1007/s00432-021-03774-5. Epub ahead of print. PMID: 34436668.

Medical therapy of HCC

Vogel, A., & Saborowski, A. (2022).
Medical therapy of HCC. Journal of Hepatology. 2022: 76(1), 208-210.
doi: https://doi.org/10.1016/j.jhep.2021.05.017

Combination therapies for targeting FGFR2 fusions in cholangiocarcinoma

Saborowski A, Vogel A, Segatto O. Combination therapies for targeting FGFR2 fusions in cholangiocarcinoma.
Trends Cancer. 2022 Feb;8(2):83-86.
doi: 10.1016/j.trecan.2021.11.001. Epub 2021 Nov 25. PMID: 34840108.

Prevalence of hepatitis delta virus among chronic hepatitis B carriers in a large tertiary center in the Netherlands

Beudeker BJB, Voermans JJC, GeurtsvanKessel CH, de Knegt RJ, Kuhlemann T, Boonstra A, van der Eijk AA.
Prevalence of hepatitis delta virus among chronic hepatitis B carriers in a large tertiary center in the Netherlands. J Clin Virol. 2021 Aug;141:104870.
doi: 10.1016/j.jcv.2021.104870. Epub 2021 Jun 18. PMID: 34182298.

Abnormal Liver Tests during Hospitalization Predict Mortality in Patients with COVID-19: A Multicenter Study from South America

Balderramo D, Mattos AZ, Mulqui V, Chiesa T, Plácido-Damián Z, Abarca J, Bolomo A, Carlino Y, Bombassaro IZ, Wiltgen D, Castillo LT, Díaz K, Acuña J, Manero E, Prieto J, Carrera E, Díaz-Ferrer J, Debes JD.
Abnormal Liver Tests during Hospitalization Predict Mortality in Patients with COVID-19: A Multicenter Study from South America. Can J Gastroenterol Hepatol. 2021 Oct 5;2021:1622533.
doi: 10.1155/2021/1622533. PMID: 34621710; PMCID: PMC8492276.

Hepatocellular carcinoma in nonalcoholic fatty liver disease: A growing challenge

Mattos ÂZ, Debes JD, Dhanasekaran R, Benhammou JN, Arrese M, Patrício ALV, Zilio AC, Mattos AA.
Hepatocellular carcinoma in nonalcoholic fatty liver disease: A growing challenge. World J Hepatol. 2021 Sep 27;13(9):1107-1121.
doi: 10.4254/wjh.v13.i9.1107. PMID: 34630878; PMCID: PMC8473502.

Immune aspects of hepatocellular carcinoma: From immune markers for early detection to immunotherapy

Mattos ÂZ, Debes JD, Boonstra A, Vogel A, Mattos AA.
Immune aspects of hepatocellular carcinoma: From immune markers for early detection to immunotherapy. World J Gastrointest Oncol. 2021 Sep 15;13(9):1132-1143.
doi: 10.4251/wjgo.v13.i9.1132. PMID: 34616518; PMCID: PMC8465446.

Potential utility of liquid biopsies in the management of patients with biliary tract cancers: A review

Shotton R, Lamarca A, Valle J, McNamara MG.
Potential utility of liquid biopsies in the management of patients with biliary tract cancers: A review. World J Gastrointest Oncol. 2021 Sep 15;13(9):1073-1085.
doi: 10.4251/wjgo.v13.i9.1073. PMID: 34616513; PMCID: PMC8465442.

Druggable molecular alterations in bile duct cancer: potential and current therapeutic applications in clinical trials

Bourien H, Lamarca A, McNamara MG, Hubner RA, Valle JW, Edeline J.
Druggable molecular alterations in bile duct cancer: potential and current therapeutic applications in clinical trials. Expert Opin Investig Drugs. 2021 Sep;30(9):975-983.
doi: 10.1080/13543784.2021.1964470. Epub 2021 Aug 22. PMID: 34420429.

The Role of Cytokines in the Different Stages of Hepatocellular Carcinoma

Rico Montanari, N.; Anugwom, C.M.; Boonstra, A.; Debes, J.D.
The Role of Cytokines in the Different Stages of Hepatocellular Carcinoma. Cancers 2021, 13, 4876. https://doi.org/10.3390/cancers13194876

Surgery for advanced intrahepatic cholangiocarcinoma warrants further investigation

Angela Lamarca*, Alvaro Santos-Laso, Kirsten Utpatel, Adelaida La Casta, Simone Stock, Alejandro Forner, Jorge Adeva, Trine Folseraas, Luca Fabris, Rocio IR Macias, Marcin Krawczyk, Marek Krawczyk, Vincenzo Cardinale, Chiara Braconi, Domenico Alvaro, Matthias Evert, Jesus M. Banales, Juan W Valle
Hepatology. May 2021 
doi: 10.1002/hep.31904

Locoregional therapies in patients with intrahepatic cholangiocarcinoma: A systematic review and pooled analysis

Edeline, Julien, Angela Lamarca, Mairéad G. McNamara, Timothy Jacobs, Richard A. Hubner, Dan Palmer, Bas Groot Koerkamp, Philip Johnson, Boris Guiu, and Juan W. Valle.
Locoregional therapies in patients with intrahepatic cholangiocarcinoma: A systematic review and pooled analysis. Cancer treatment reviews 99 (2021): 102258.
doi: https://doi.org/10.1016/j.ctrv.2021.102258

Current impact of viral hepatitis on liver cancer development: The challenge remains

de Mattos ÂZ, Debes JD, Boonstra A, Yang JD, Balderramo DC, Sartori GDP, de Mattos AA.
Current impact of viral hepatitis on liver cancer development: The challenge remains. World J Gastroenterol. 2021 Jun 28;27(24):3556-3567.
doi: 10.3748/wjg.v27.i24.3556. PMID: 34239269; PMCID: PMC8240060.

Next-Generation Biomarkers for Cholangiocarcinoma

Rodrigues PM, Vogel A, Arrese M, Balderramo DC, Valle JW, Banales JM.
Next-Generation Biomarkers for Cholangiocarcinoma. Cancers (Basel). 2021 Jun 28;13(13):3222.
doi: 10.3390/cancers13133222. PMID: 34203269; PMCID: PMC8269024.

Insights into Nonalcoholic Fatty-Liver Disease Heterogeneity

Arrese M, Arab JP, Barrera F, Kaufmann B, Valenti L, Feldstein AE.
Insights into Nonalcoholic Fatty-Liver Disease Heterogeneity. Semin Liver Dis. 2021 Nov;41(4):421-434.
doi: 10.1055/s-0041-1730927. Epub 2021 Jul 7. PMID: 34233370; PMCID: PMC8492194.

Perspectives on Precision Medicine Approaches to NAFLD Diagnosis and Management

Lonardo, Amedeo, Juan Pablo Arab, and Marco Arrese. 
Advances in Therapy (2021): 1-29.
doi: https://doi.org/10.6084/m9.figshare.14113481

Pathogenesis of Cholangiocarcinoma

Rodrigues, Pedro M., Paula Olaizola, Nuno A. Paiva, Irene Olaizola, Alona Agirre-Lizaso, Ana Landa, Luis Bujanda, Maria J. Perugorria, and Jesus M. Banales.  
Annual Review of Pathology: Mechanisms of Disease 16 (2020).
doi: https://doi.org/10.1146/annurev-pathol-030220-020455

HPB cancers in older patients| inclusion of older/senior patients in clinical trials.

Backen, Alison, Angela Lamarca, Richard A. Hubner, Mairéad G. McNamara, and Juan W. Valle.
European Journal of Surgical Oncology 47, no. 3 (2021): 597-602.
doi: https://doi.org/10.1016/j.ejso.2020.11.002

Targeted therapies for extrahepatic cholangiocarcinoma: preclinical and clinical development and prospects for the clinic.

Cadamuro, Massimiliano, Alberto Lasagni, Angela Lamarca, Laura Fouassier, Maria Guido, Samantha Sarcognato, Enrico Gringeri et al. 
Expert opinion on investigational drugs (2021): 1-11.
doi: https://doi.org/10.1080/13543784.2021.1880564

Reply to “Does multiple intrahepatic cholangiocarcinoma worsen prognosis as “M1” stage?”; multiple primaries vs liver metastases.

Lamarca, Angela, Alvaro Santos‐Laso, Kirsten Utpatel, Adelaida La Casta, Simone Stock, Alejandro Forner, Jorge Adeva et al.
Hepatology (2021).
doi: https://doi.org/10.1002/hep.31740

Ivosidenib: an investigational drug for the treatment of biliary tract cancers

Angelakas, Angelos, Angela Lamarca, Richard A. Hubner, Mairéad G. McNamara, and Juan W. Valle.  
Expert opinion on investigational drugs (2021).
doi: https://doi.org/10.1080/13543784.2021.1900115

Immunotherapies in clinical development for biliary tract cancer.

Vogel, Arndt, Melanie Bathon, and Anna Saborowski.
Expert Opinion on Investigational Drugs (2021): 1-13.
doi: https://doi.org/10.1080/13543784.2021.1868437

Advances in systemic therapy for the first-line treatment of unresectable HCC.

Vogel, Arndt, Melanie Bathon, and Anna Saborowski.
Expert Review of Anticancer Therapy (2021).
doi: https://doi.org/10.1080/14737140.2021.1882855

Current and Future Systemic Therapies in Biliary Tract Cancer.

Vogel, Arndt, and Anna Saborowski. 
Visceral medicine 37, no. 1 (2021): 32-38.
doi: https://doi.org/10.1159/000513969

Hepatitis B-related hepatocellular carcinoma: surveillance strategy directed by immune-epidemiology

Anugwom, Chimaobi M., Manon Allaire, Sheikh Mohammad Fazle Akbar, Amir Sultan, Steven Bollipo, Angelo Z. Mattos, and Jose D. Debes. 
Hepatoma research 7 (2021).
doi: 10.20517/2394-5079.2021.06

Implicit bias in region-dependent publication potential can partly be counteracted by Academic collaboration

Peppelenbosch, Maikel P., and Carmen V. Ferreira.
Clinical Gastroenterology and Hepatology (2021).
doi: https://doi.org/10.1016/j.cgh.2021.04.001

Serum Biomarkers for the Prediction of Hepatocellular Carcinoma

Debes, José D., Pablo A. Romagnoli, Jhon Prieto, Marco Arrese, Angelo Z. Mattos, André Boonstra, and Escalon Consortium.
Cancers 13, no. 7 (2021): 1681.
doi: https://doi.org/10.3390/cancers13071681

Hepatitis B core-related antigen levels predict recurrence-free survival in patients with HBV-associated early-stage hepatocellular carcinoma: results from a Dutch long-term follow-up study.

Beudeker BJB, Groothuismink ZMA, de Man RA, Witjes CDM, van der Eijk AA, Boonstra A, Sonneveld MJ. 
J Viral Hepat. 2021 Jan;28(1):205-208. doi: 10.1111/jvh.13394.
doi : https://doi.org/10.1111/jvh.13394

Current and novel therapeutic opportunities for systemic therapy in biliary cancer.

Marin JJG, Prete MG, Lamarca A, Tavolari S, Landa-Magdalena A, Brandi G, Segatto O, Vogel A, Macias RIR, Rodrigues PM, Casta A, Mertens J, Rodrigues CMP, Fernandez-Barrena MG, Da Silva Ruivo A, Marzioni M, Mentrasti G, Acedo P, Munoz-Garrido P, Cardinale V, Banales JM, Valle JW, Bridgewater J, Braconi C; working group 6 of the COST-action 18122 (Euro-Cholangio-NET) as part of the European Network for the study of Cholangiocarcinoma (ENSCCA).
Br J Cancer. 2020 Sep;123(7):1047-1059. doi: 10.1038/s41416-020-0987-3.

Pilot Multi-Omic Analysis of Human Bile from Benign and Malignant Biliary Strictures: A Machine-Learning Approach

Jesús M Urman, José M Herranz, Iker Uriarte, María Rullán, Daniel Oyón, Belén González, Ignacio Fernandez-Urién, Juan Carrascosa, Federico Bolado, Lucía Zabalza, María Arechederra , Gloria Alvarez-Sola, Leticia Coly, María U Latasa, Leonor Puchades-Carrasco, Antonio Pineda-Lucena , María J Iraburu, Marta Iruarrizaga-Lejarreta, Cristina Alonso, Bruno Sangro, Ana Purroy, Isabel Gil, Lorena Carmona, Francisco Javier Cubero, María L Martínez-Chantar, Jesús M Banales, Marta R Romero, Rocio I R Macias, Maria J Monte, Jose J G Marín, Juan J Vila, Fernando J Corrales , Carmen Berasain, Maite G Fernández-Barrena, Matías A Avila
Cancers 2020, 12(6), 1644; https://doi.org/10.3390/cancers12061644

Cholangiocarcinoma 2020: the next horizon in mechanisms and management.

Jesus M. Banales, Jose J. G. Marin, Angela Lamarca, Pedro M. Rodrigues, Shahid A. Khan, Lewis R. Roberts, Vincenzo Cardinale, Guido Carpino, Jesper B. Andersen, Chiara Braconi, Diego F. Calvisi, Maria J. Perugorria, Luca Fabris, Luke Boulter, Rocio I. R. Macias, Eugenio Gaudio, Domenico Alvaro, Sergio A. Gradilone, Mario Strazzabosco, Marco Marzioni, Cédric Coulouarn, Laura Fouassier, Chiara Raggi, Pietro Invernizzi, Joachim C. Mertens, Anja Moncsek, Sumera Rizvi, Julie Heimbach, Bas Groot Koerkamp, Jordi Bruix, Alejandro Forner, John Bridgewater, Juan W. Valle & Gregory J. Gores
Nat Rev Gastroenterol Hepatol 17, 557–588 (2020). https://doi.org/10.1038/s41575-020-0310-z

A Novel Serum Metabolomic Profile for the Differential Diagnosis of Distal Cholangiocarcinoma and Pancreatic Ductal Adenocarcinoma.

Macias RIR, Muñoz-Bellvís L, Sánchez-Martín A, Arretxe E, Martínez-Arranz I, Lapitz A, Gutiérrez ML, La Casta A, Alonso C, González LM, Avila MA, Martinez-Chantar ML, Castro RE, Bujanda L, Banales JM, Marin JJG.
Cancers (Basel). 2020 May 31;12(6):1433. doi: 10.3390/cancers12061433

Current and New Biomarkers for Early Detection, Prognostic Stratification, and Management of Gallbladder Cancer Patients.

García P, Lamarca A, Díaz J, Carrera E, Roa JC, on behalf of the European-Latin American ESCALON Consortium. 
Cancers. 2020; 12(12):3670. https://doi.org/10.3390/cancers12123670

Functional and genomic characterization of three novel cell lines derived from a metastatic gallbladder cancer tumor

García, P., Bizama, C., Rosa, L., Espinoza, J. A., Weber, H., Cerda-Infante, J., Sánchez, M., Montecinos, V. P., Lorenzo-Bermejo, J., Boekstegers, F., Dávila-López, M., Alfaro, F., Leiva-Acevedo, C., Parra, Z., Romero, D., Kato, S., Leal, P., Lagos, M., & Roa, J. C.
Biological research 2020, 53(1), 13. https://doi.org/10.1186/s40659-020-00282-7

Evaluation of the chemopreventive potentials of ezetimibe and aspirin in a novel mouse model of gallbladder preneoplasia

Rosa, L., Lobos‐González, L., Muñoz‐Durango, N., García, P., Bizama, C., Gómez, N., González, X., Wichmann, I.A., Saavedra, N., Guevara, F., Villegas, J., Arrese, M., Ferreccio, C., Kalergis, A.M., Miquel, J.F., Espinoza, J.A. and Roa, J.C.
Mol Oncol. Accepted Author Manuscript 2020. doi:10.1002/1878-0261.12766

Circulating biomarkers for early detection of hepatocellular carcinoma

Beudeker BJ, Boonstra A.
Therapeutic Advances in Gastroenterology. 2020 Jun;13:1756284820931734.

Patients with Cholangiocarcinoma Present Specific RNA Profiles in Serum and Urine Extracellular Vesicles Mirroring the Tumor Expression: Novel Liquid Biopsy Biomarkers for Disease Diagnosis.

Lapitz A, Arbelaiz A, O'Rourke CJ, Lavin JL, Casta A, Ibarra C, Jimeno JP, Santos-Laso A, Izquierdo-Sanchez L, Krawczyk M, Perugorria MJ, Jimenez-Aguero R, Sanchez-Campos A, Riaño I, Gónzalez E, Lammert F, Marzioni M, Macias RIR, Marin JJG, Karlsen TH, Bujanda L, Falcón-Pérez JM, Andersen JB, Aransay AM, Rodrigues PM, Banales JM
Cells. 2020; 14;9(3). pii: E721. doi: 10.3390/cells9030721.

Hepatocellular carcinoma - unraveling the role of occult hepatitis B virus infection.

Mattos ÂZ, Mattos AA, Debes JD.
Clin Gastroenterol Hepatol. 2020; pii: S1542-3565(20)30338-4. doi: 10.1016/ j.cgh.2020.03.028.

Hippo-YAP1 Is a Prognosis Marker and Potentially Targetable Pathway in Advanced Gallbladder Cancer.

García P, Rosa L, Vargas S, Weber H, Espinoza JA, Suárez F, Romero-Calvo I, Elgueta N, Rivera V, Nervi B, Obreque J, Leal P, Viñuela E, Aguayo G, Muñiz S, Sagredo A, Roa JC, Bizama C.
Cancers (Basel). 2020;12(4): E778. doi: 10.3390/cancers12040778.

NAFLD-Related Hepatocellular Carcinoma and the Four Horsemen of the Apocalypse

Jose D. Debes, Andre Boonstra, Robert J. de Knegt
Hepatology. 2020.
71: 774-776. doi:10.1002/hep.31170

Diagnostic and prognostic biomarkers in cholangiocarcinoma

Macias RI, Kornek M, Rodrigues PM, Paiva NA, Castro RE, Urban S, Pereira SP, Cadamuro M, Rupp C, Loosen SH, Luedde T.
Liver International. 2019 May;39:108-22.

Hepatocellular carcinoma, a unique tumor with a lack of biomarkers

Debes JD, Carrera E, Mattos AZ, Prieto JE, Boonstra A; ESCALON investigators. 
Ann Hepatol. 2019; pii: S1665-2681(19)32214-8. doi: 10.1016/
j.aohep.2019.07.009 PMID: 31494068.

Hepatobiliary cancers in South America: disparity strikes

Debes JD, Boonstra A, Balderramo D, Mattos AZ, Arrese M; ESCALON investigators.
Lancet Gastroenterol Hepatol. 2019; 4:581. doi: 10.1016/S2468-1253(19)30188-8 PMID: 31292069.

Serum Metabolites as Diagnostic Biomarkers for Cholangiocarcinoma, Hepatocellular Carcinoma, and Primary Sclerosing Cholangitis

Banales JM, Iñarrairaegui M, Arbelaiz A, Milkiewicz P, Muntané J, Muñoz-Bellvis L, La Casta A, Gonzalez LM, Arretxe E, Alonso C, Martínez-Arranz I, Lapitz A, Santos-Laso A, Avila MA, Martínez-Chantar ML, Bujanda L, Marin JJG, Sangro B, Macias RIR
Hepatology. 2019;70(2):547-562. doi: 10.1002/hep.30319

Sorafenib for Treatment of Hepatocellular Carcinoma: A Survival Analysis From the South American Liver Research Network

S Leathers J, Balderramo D, Prieto J, Diehl F, Gonzalez-Ballerga E, Ferreiro MR, Carrera E, Barreyro F, Diaz-Ferrer J, Singh D, Mattos AZ, Carrilho F, Debes JD
J Clin Gastroenterol. 2019; 53:464-469. doi: 10.1097/
MCG. 0000000000001085.

Levels of cytokines in serum associate with development of hepatocellular carcinoma in patients with HCV infection treated with direct-acting antivirals.

Debes JD, van Tilborg M, Groothuismink ZMA, Hansen BE, Schulze Zur Wiesch J, von Felden J, de Knegt RJ, Boonstra A.
Gastroenterology.2018;154:515-517.e3.doi:10.1053/ j.gastro.2017.10.035

Hepatocellular carcinoma in South America: Evaluation of risk factors, demographics and therapy

Debes JD, Chan AJ, Balderramo D, Kikuchi L, Gonzalez Ballerga E, Prieto JE, Tapias M, Idrovo V, Davalos MB, Cairo F, Barreyro FJ, Paredes S, Hernandez N, Avendaño K, Diaz Ferrer J, Yang JD, Carrera E, Garcia JA, Mattos AZ, Hirsch BS, Gonçalves PT, Carrilho FJ, Roberts LR
Liver Int. 2018; 38:136-143. doi: 10.1111/liv.13502.

Serum extracellular vesicles contain protein biomarkers for primary sclerosing cholangitis and cholangiocarcinoma

Arbelaiz A, Azkargorta M, Krawczyk M, Santos-Laso A, Lapitz A, Perugorria MJ, Erice O, Gonzalez E, Jimenez-Agüero R, Lacasta A, Ibarra C, Sanchez-Campos A, Jimeno JP, Lammert F, Milkiewicz P, Marzioni M, Macias RIR, Marin JJG, Patel T, Gores GJ, Martinez I, Elortza F, Falcon-Perez JM, Bujanda L, Banales JM
Hepatology. 2017; 66:1125-1143. doi: 10.1002/hep.29291.

Early Age Hepatocellular Carcinoma Associated With Hepatitis B Infection in South America

Chan AJ, Balderramo D, Kikuchi L, Ballerga EG, Prieto JE, Tapias M, Idrovo V, Davalos MB, Cairo F, Barreyro FJ, Paredes S, Hernandez N, Avendaño K, Ferrer JD, Yang JD, Carrera E, Mattos AZ, Hirsch BS, Gonçalves PT, Carrilho FJ, Roberts LR, Debes JD
Clin Gastroenterol Hepatol. 2017; 15:1631-1632. doi: 10.1016/
j.cgh.2017.05.015.

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